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psdA [2018-05-04 16:31:42]
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psdA [2018-05-04 16:31:42]

ABC transporter (ATP-binding protein) for the export of lipid II-binding lantibiotics, such as nisin and gallidermin
Locus
BSU34700
Isoelectric point
6.34
Molecular weight
28.89 kDa
Protein length
259 aa Sequence Blast
Gene length
777 bp Sequence Blast
Function
export of toxic peptides
Product
ABC transporter (ATP-binding protein)
Essential
no
Synonyms
yvcR
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Cellular processes → Transporters → ABC transporters → Exporters → Export of peptides
  • Lifestyles → Coping with stress → Resistance against toxins/ antibiotics
  • Groups of genes → Membrane proteins

    • Gene

    Coordinates
    3,565,496 → 3,566,275

    The protein

    Structure

  • 1L2T (MJ0796 from Methanocaldococcus jannaschii , 44% identity) PubMed

    • Localization

  • membrane associated (via PsdB) PubMed

    • Expression and Regulation

    Operons

    Genes
    psdR-psdS-psdA-psdB
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • PsdR: activation, PubMed, in PsdR regulon

    • Regulation

  • psdA: induced by nisin, gallidermin (PsdR) PubMed
    • view in new tab

    Genes
    psdA-psdB
    Description
    PubMed

    Regulation

  • psdA: induced by nisin, gallidermin (PsdR) PubMed
    • view in new tab

    Biological materials

    Mutant

  • MGNA-B635 (yvcR::erm), available at the NBRP B. subtilis, Japan
  • BKE34700 (ΔpsdA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGTTCTGCTCCTCCTTTT, downstream forward: _UP4_TTGAGTGTGTTGGGAGGCGA
  • BKK34700 (ΔpsdA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGTTCTGCTCCTCCTTTT, downstream forward: _UP4_TTGAGTGTGTTGGGAGGCGA

    • References

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